A safety shadow cast over paclitaxel-impregnated stents and devices

Paclitaxel-coated balloons and stents reduce restenosis and target lesion revascularization after lower extremity interventions, but what of long term outcomes? A recent systematic review and meta-analysis of RCTs investigating paclitaxel-coated devices in the femoral...

Ketamine for depression

There has been considerable interest in the potential clinical efficacy of ketamine for the management of depression, albeit there is also concern about the durability of benefit and potential adverse effects, especially in the longer term. Read more in excellent...

What is the best treatment option for recurrent C Difficile infection?

In a small prospective clinical trial, researchers randomly assigned people with recurrent C Diff infection to receive fecal microbiota transplantation (FMT), applied by colonoscopy or nasojejunal tube after 4–10 days of vancomycin (125 mg 4 times daily, comparing...

Penicillin allergy primer

β-Lactam antibiotics are wide used for a reason – they are safe and effective antibiotics. Recent reports of issues with other drugs have served to emphasize this, for example the multiplicity of issues associated with flouroquinolones that has been prominent in...