FDA issues gabapentinoid warning statement

The US FDA have issued a warning about the risks of co-prescribing gabapentinoids with other respiratory depressants. An extract from the statement: Health care professionals should start gabapentinoids at the lowest dose and monitor patients for symptoms of...

Testosterone supplementation increases risk of VTE

A case-crossover study conducted in the USA has investigated the relationship between testosterone therapy and short-term risk of venous thromboembolism (VTE) in men with and without hypogonadism. The study spanned across January 2011 to December 2017 and included...

Baclofen and risk of encephalopathy in CKD

As baclofen has been associated with encephalopathy in patients with chronic kidney disease (CKD), Canadian researchers have recently conducted a retrospective cohort study comparing the 30-day incidence risk between patients taking ≥ 20 mg baclofen per day and those...

Blood glucose at hospital discharge – lower is not necessarily better

A nationwide cohort study conducted in the US assessed whether people with diabetes who had with low blood glucose concentrations at the time of hospital discharge were at a higher risk of 30-day readmission or mortality. The study included 843,978 diabetic patients...

Risperidone and osteoporotic bone fractures

Another reason to be concerned about the long term effects of antipsychotic drugs is that they may cause hyperprolactinaemia, which as well as causing issues such as gynaecomastia and amenorrhea may also contribute to bone loss. The effect of antipsychotics,...