When it comes to antihypertensive treatment, timing seems to matter…

The Hygia Chronotherapy Trial, recently conducted in Spain, has assessed the effect of the timing of hypertension therapy upon cardiovascular disease (CVD) risk reduction. The multi-centre, controlled, prospective trial included 19,084 hypertensive patients (mean age...

BMJ Safety and Quality study addresses look-alike, sound alike errors

Researchers have recently assessed the specificity of an algorithm to detect look-alike/sound-alike (LASA) medication prescribing errors in electronic health record (EHR) data: data derived from eight years of medication orders and diagnostic claims were analysed. The...

DOACs appear to trump warfarin in extended anticoagulation

A systematic review and meta-analysis recently published by the American College of Chest Physicians has assessed the effects of vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) during extended anticoagulation for VTE events, addressing both overall...

Shingles risk up for RA patients receiving DMARDs + steroids

While herpes zoster (HZ) has been linked to JAK inhibitors such as tofacitinib, it is unclear whether concomitant methotrexate (MTX) and/or glucocorticoids increase this risk. In a recent American study, HZ risk has been assessed in tofacitinib-treated rheumatoid...