RCTs don’t necessarily represent the wider population

A recent meta-analysis has investigated differences between dialysis-dependent participants in large, multi-centre randomised clinical trials (RCTs) and other people from the general population undergoing dialysis. Differences in age, comorbidities and mortality rate...

Making drug interactions relevant again

Prescribers can overlook important alerts because of common alert fatigue arising from a hail of false-positive drug-drug interaction (DDI) alerts. To make alerts relevant again, the development of more appropriate alerts is required. The potential for...

Fatalities associated with insect stings. Are medications implicated?

New data from the US Center for Disease Control suggests that the prevalence of death after insect stings may be rising. Are the insects getting more poisonous, or is there another possible reason. One possibility to consider is that the use of ACE inhibitors and ARB...

Early physio = less later opioids

An analysis of health insurance claims data for people who presented with musculoskeletal pain to an outpatient physician office or an emergency department in the US assessed information from 88 985 opioid-naive patients aged 18 to 64 years with a new diagnosis of...

Intensive BGL control probably not warranted after stroke

American researchers have recently examined the question  of whether intensive glucose control improves functional outcome amongst people with hyperglycaemia after acute ischemic stroke. This was a randomised clinical trial included of 1151 adults (mean age 66 years)...