While tumour necrosis factor-α (TNFα) inhibitors have been shown to increase risk of serious infection in adult treated for inflammatory bowel disease (IBD), the association between their use and risk of serious infection in children with IBD remains inconclusive. A...
Advice issued by the Australian Advisory Committee on Medicines. Thiopurines (azathioprine, mercaptopurine, tioguanine) People with a deficiency in the thiopurine methyltransferase (TPMT) gene have greater susceptible to serious thiopurine toxicities...
The relationship between exploratory and confirmatory post-approval trials for pregabalin (Lyrica) has been recently analysed by Canadian researchers, who conducted a systematic review of all clinical trials testing the effectiveness of pregabalin in non-approved...
Sodium-glucose co-transporter-2 (SGLT2) inhibitors (“gliflozins”) are being used increasingly for the management of of Type 2 Diabetes Mellitus. Acting by promoting urinary glucose excretion, the drugs have been approved as a safe and effective treatment but concerns...
A nested case-control study recently published in the BMJ has investigated the link between antidepressant (AD) classes, of use throughout pregnancy and gestational diabetes mellitus (GDM) risk. 20,905 cases of GDM were observed following week 20 of pregnancy and...
