From the archives – Age-adjusted warfarin initiation

An important study published more than 15 years ago, and which has stood the test of time. The South Australian researchers found that an age-adjusted dosing protocol rapidly achieved a stable INR with minimal overanticoagulation. Those with low serum albumin levels (<3.0 g/dL) may be sensitive to the effects of warfarin during the loading phase. Not all warfarin initiation regimens are equal!