Many people find it difficult to quit smoking, even when it is clear that the habit is causing them harm. In a study reported here, researchers found that nicotine withdrawal for smokers may adversely effect pain perception.Extended nicotine deprivation (relative to continued smoking) increased capsaicin-induced pain intensity ratings, neurogenic inflammation, and mechanical hyperalgesia, and pain intensity ratings were also positively correlated with nicotine withdrawal symptoms. Smokers with pain may require addition support during quit attempts.