Baclofen and risk of encephalopathy in CKD

As baclofen has been associated with encephalopathy in patients with chronic kidney disease (CKD), Canadian researchers have recently conducted a retrospective cohort study comparing the 30-day incidence risk between patients taking ≥ 20 mg baclofen per day and those...

Blood glucose at hospital discharge – lower is not necessarily better

A nationwide cohort study conducted in the US assessed whether people with diabetes who had with low blood glucose concentrations at the time of hospital discharge were at a higher risk of 30-day readmission or mortality. The study included 843,978 diabetic patients...

Risperidone and osteoporotic bone fractures

Another reason to be concerned about the long term effects of antipsychotic drugs is that they may cause hyperprolactinaemia, which as well as causing issues such as gynaecomastia and amenorrhea may also contribute to bone loss. The effect of antipsychotics,...

DOACs appear safer than warfarin after mild traumatic brain injury

Treatments used for patients after mild traumatic brain injury (MTBI) may need to include direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs), however the associated risk of intracranial haemorrhage (ICH) associated with DOACs remains unclear. To...

Lithium in pregnancy – increased risk, but some benefits too

American researchers have recently published a systematic review and meta-analysis examining the safety, efficacy and risks associated with lithium treatment during pregnancy and the postpartum period for women with bipolar disorder. Following analysis of thirteen...