Genomic predisposition to poorer outcomes with clopidogrel

The link between the AKR1D1*36 (rs1872930) allele and risk of major adverse cardiovascular and cerebrovascular events (MACCE) in patients taking clopidogrel has been examined in a recent observational pharmacogenomic cohort study. 118 patients (median age 62.5 years)...

Alzheimer’s and adverse drug reactions

The increasing incidence of Alzheimer’s disease has seen an accompanying increase in adverse drug events (ADEs) related to various psychotropic medications used by these patients. To assess the prevalence and economic burden of psychotropic ADEs, American...

When it comes to antihypertensive treatment, timing seems to matter…

The Hygia Chronotherapy Trial, recently conducted in Spain, has assessed the effect of the timing of hypertension therapy upon cardiovascular disease (CVD) risk reduction. The multi-centre, controlled, prospective trial included 19,084 hypertensive patients (mean age...

BMJ Safety and Quality study addresses look-alike, sound alike errors

Researchers have recently assessed the specificity of an algorithm to detect look-alike/sound-alike (LASA) medication prescribing errors in electronic health record (EHR) data: data derived from eight years of medication orders and diagnostic claims were analysed. The...