Oct 28, 2019
A systematic review and meta-analysis recently published by the American College of Chest Physicians has assessed the effects of vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) during extended anticoagulation for VTE events, addressing both overall...
Oct 24, 2019
While herpes zoster (HZ) has been linked to JAK inhibitors such as tofacitinib, it is unclear whether concomitant methotrexate (MTX) and/or glucocorticoids increase this risk. In a recent American study, HZ risk has been assessed in tofacitinib-treated rheumatoid...
Oct 24, 2019
Commonly prescribed drugs appear to have an important impact on the gut microbiome. Researchers from the Netherlands reported that 18 common drug classes appear to have been associated with alterations in gut flora profiles. The research involved metagenomic...
Oct 21, 2019
While tumour necrosis factor-α (TNFα) inhibitors have been shown to increase risk of serious infection in adult treated for inflammatory bowel disease (IBD), the association between their use and risk of serious infection in children with IBD remains inconclusive. A...
Oct 18, 2019
Advice issued by the Australian Advisory Committee on Medicines. Thiopurines (azathioprine, mercaptopurine, tioguanine) People with a deficiency in the thiopurine methyltransferase (TPMT) gene have greater susceptible to serious thiopurine toxicities...
Oct 16, 2019
The relationship between exploratory and confirmatory post-approval trials for pregabalin (Lyrica) has been recently analysed by Canadian researchers, who conducted a systematic review of all clinical trials testing the effectiveness of pregabalin in non-approved...
