How does polypharmacy cause falls?

Polypharmacy has long been thought to be linked to increased incidence of falls. A recent Canadian cohort study assessing community‐dwelling older adults included 5 years of follow‐up to assess this issue amongst people aged 65 years and older (n = 249; 76.6 ± 8.6 y;...

Long-term side effects of PPIs assessed in large RCT

Discussion about the long term side effects of Proton pump inhibitors (PPIs) continues, but almost all meaningful data to date have been derived from pharmacoepidemiological studies based upon naturalistic observational techniques. A large randomized trial has now...

Medical cannabis – impact on opioid use in pain

Medical Cannabis may impact opioid and benzodiazepine requirements for pain control, according to recent research from the USA. A single-center, retrospective cohort study evaluated opioid and benzodiazepine doses over a 6-month time period for patients using medical...

Vancomycin for mild – moderate C Difficile infection

A recently published review has compared oral metronidazole and vancomycin for the treatment of mild-to-moderate C difficile infection. The authors found evidence of superior efficacy with vancomycin, and also a lower cost of treatment per case for hospitalized...

Management of recurrent Clostridium difficile infections

Recurrent Clostridium difficile infection has been defined as a relapse of symptoms within 2 -8 weeks of successful treatment of an initial episode, and depending upon interpretation is said to occur in up to 35% of people with C difficile infection. A recent review...