Benefits of aspirin for secondary prevention fail to ARRIVE

The ARRIVE study was a LARGE randomised, double-blind, placebo-controlled, multicentre. Men aged 55 years and older or women 60 years or older and with moderate cardiovascular risk. Patients were randomly assigned (1:1) to receive enteric-coated aspirin 100 mg or...

TCAs should be avoided after major cardiovascular events

Antidepressants are amongst the very widely prescribed medications in many nations. Researchers have recently studied the association of antidepressants with major adverse cardiovascular events (including death). In a historical study of 1266 patients who completed...

Pharmacy pre-review impacts opioid prescribing

With so much attention being focused on the harm associated with prescription opioid use, especially amongst people treated with high dose opioids for chronic pain, interventions focused upon achieving harm reduction are most welcome.  Researchers have recently...

Problematic drug interactions with antimicrobials

American researchers have recently studied the potential for serious drug interactions involving antimicrobial agents, in a report published in Clinical Microbiology and Infection. The researchers studied national-level patterns of contraindications between oral...