There has been a lot of hype about the use of ketamine to produce a rapid antidepressant effect, but the fact remains that the effect is arher short-lived. Recent research was conducted to assess if lithium was more effective than placebo as a continuation strategy following to sustain the antidepressant effect ketamine in people with treatment resistant depression. No difference between lithium and placebo was observed for this purpose – for now, thee search must continue. Read more here