Concerns about gabapentinoid abuse potential grows

Concern continues to evolve over the potential for abuse of gabapentinoid drugs (gabapentin, topiramate, and most notably, pregabalin). One reason underpinning this concern is the observations that 1) euphoria and dissociation seem to be dose-dependent adverse effects...

Probiotics fail to deliver for children with gastroenteritis

Acute gastroenteritis is a common reason for emergency department visits amongst young children. Although advocated vigorously by some, probiotics have not been properly assessed as regards their propensity to improve outcomes in childhood gastroenteritis. A recent...

Inappropriate prescribing may begin in hospital

It is well-known that older people are the most extensive users of prescribed medications, albeit for many reasons this sub-population is at greatest risk for medication-related problems. Although a great deal of medication prescribing in primary care is repeat...

Big Pharma dragging the chain on completion of pediatric studies

In the USA, the Pediatric Research Equity Act of 2003 means that the US FDA can require sponsor pharmaceutical companies to conduct specifif pediatric clinical studies, in order that the approved product information can incorporate proper prescribing guidance for...

Pharmacists effective in facilitating deprescribing

In 2015 the American Geriatrics Society promulgated an updated version of the “Beers Criteria” list of drugs to avoid in older adults, drugs that are unsuited for use in the older person because of the risk of harm and availability of safer treatments....